Biological signaling by carbon monoxide and carbon monoxide-releasing molecules
نویسندگان
چکیده
منابع مشابه
Biological signaling by carbon monoxide and carbon monoxide-releasing molecules.
Carbon monoxide (CO) is continuously produced in mammalian cells during the degradation of heme. It is a stable gaseous molecule that reacts selectively with transition metals in a specific redox state, and these characteristics restrict the interaction of CO with defined biological targets that transduce its signaling activity. Because of the high affinity of CO for ferrous heme, these targets...
متن کاملCarbon Monoxide Releasing Pharmaceuticals
Carbon monoxide (CO) was ignored by the medical research community for decades, who thought that no biological relevance could emerge from exploring the physiological effects of a gas that had earned itself a reputation over the years as a ‘silent killer’ [2] . The well-known poisoning by carbon monoxide is a result of it binding to Hemoglobin, the oxygen carrier in blood with very high affinit...
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Carbon monoxide (CO) is generated in living organisms during the degradation of heme by the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible (HO-1) isoforms. Carbon monoxide gas is known to dilate blood vessels in a manner similar to nitric oxide and has been recently shown to possess antiinflammatory and antiapoptotic properties. We report that a series of tran...
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Carbon monoxide-releasing molecules (CO-RMs) are compounds capable of delivering controlled amounts of CO within a cellular environment. Ruthenium-based carbonyls [tricarbonyldichloro ruthenium(II) dimer and tricarbonylchloro-(glycinato)ruthenium(II)] and boronacorbonates (sodium boranocarbonate) have been shown to promote vasodilatory, cardioprotective, and anti-inflammatory activities in a va...
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Carbon monoxide (CO) generated by the enzyme heme oxygenase during the breakdown of heme is known to mediate a number of biological effects. Here, we investigated whether CO liberated from a water-soluble CO-releasing molecule (CO-RM) is capable of modulating leukocyte-endothelial interactions. Tricarbonylchoro(glycinato)ruthenium (II) (CORM-3), a fast CO releaser, proved to be anti-inflammator...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2017
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00360.2016